SARS-CoV-2 Infection during the Omicron Surge among Patients Receiving Dialysis: The Role of Circulating Receptor-Binding Domain Antibodies and Vaccine Doses.

Maria E Montez-RathPablo GarciaJialin HanLinaCel CaddenPatti HunsaderCurt MorganRussell KerschmannPaul BeyerMary O DittrichGeoffrey A BlockJulie ParsonnetGlenn M ChertowShuchi Anand

Published in: Journal of the American Society of Nephrology : JASN (2022)

Among patients receiving dialysis, a third mRNA vaccine dose enhanced protection against SARS-CoV-2 infection during the Omicron-dominant period, but a low circulating RBD antibody response was associated with risk for infection independent of the number of vaccine doses. Measuring circulating antibody levels in this high-risk group could inform optimal timing of vaccination and other measures to reduce risk of SARS-CoV-2 infection.

Keyphrases

respiratory syndrome coronavirus
chronic kidney disease
end stage renal disease
binding protein
sars cov
peritoneal dialysis
dna binding
transcription factor