Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze.
Hooman MirzakhaniAmal A Al-GarawiVincent J CareyWeiliang QiuAugusto A LitonjuaScott T WeissPublished in: Thorax (2018)
Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.
Keyphrases
- cord blood
- early life
- transforming growth factor
- network analysis
- chronic obstructive pulmonary disease
- epithelial mesenchymal transition
- genome wide
- lung function
- pregnant women
- allergic rhinitis
- clinical trial
- genome wide identification
- gene expression
- phase iii
- phase ii
- genome wide analysis
- gestational age
- signaling pathway
- pregnancy outcomes