Cutibacterium acnes invades prostate epithelial cells to induce BRCAness as a possible pathogen of prostate cancer.

Shingo AshidaChiaki KawadaHiroko TanakaAtsushi KurabayashiKen-Ichi YagyuShuji SakamotoKazuhiro MaejimaSatoru MiyanoMasanori DaibataHidewaki NakagawaKeiji Inoue

Published in: The Prostate (2024)

These findings suggest that C. acnes infection in the prostate could lead to HR deficiency (BRCAness) which promotes DNA double-strand breaks, thereby increasing the risk of cancer development.

Keyphrases

prostate cancer
radical prostatectomy
papillary thyroid
benign prostatic hyperplasia
circulating tumor
squamous cell
cell free
single molecule
squamous cell carcinoma
lymph node metastasis
replacement therapy
childhood cancer
circulating tumor cells