Impact of superovulation and in vitro fertilization on LINE-1 copy number and telomere length in C57BL/6 J mice blastocysts.

Thalita S Berteli Fang Wang Fabiana Barzotto Kohlrausch Caroline Mantovani Da Luz Fernanda V Oliveira David Lawrence Keefe Paula Andrea Navarro

Published in: Molecular biology reports (2022)

Intriguingly ovarian stimulation, alone or followed by IVF, produced embryos with significantly longer telomeres compared to in vivo, natural cycle-produced embryos. The significance of this enriched telomere endowment for the health and longevity of offspring born from IVF merit future studies.

Keyphrases

copy number
mitochondrial dna
pregnancy outcomes
genome wide
public health
healthcare
dna methylation
high fat diet
high fat diet induced
mental health
current status
gestational age
low birth weight
adipose tissue
gene expression
type diabetes
insulin resistance
metabolic syndrome
wild type