Plasma TDP-43 Reflects Cortical Neurodegeneration and Correlates with Neuropsychiatric Symptoms in Huntington's Disease.
Frederic SampedroSaul Martínez-HortaJesus Pérez-PérezRocío Pérez-GonzálezAndrea Horta-BarbaAntonia CampolongoCristina IzquierdoIgnacio Aracil-BolañosElisa RivasArnau Puig-DaviJavier PagonabarragaBeatriz Gómez-AnsónJaime KulisevskyPublished in: Clinical neuroradiology (2022)
Our results suggest that the presence of TDP-43 pathology in HD has an independent contribution to the severity of neuropsychiatric symptoms and frontotemporal degeneration. These findings point out the importance of TDP-43 as an additional pathological process to be taken into consideration in this devastating disorder.