Streptococcus mutans inhibits the growth of Enterococcus via the non-ribosomal cyclic peptide mutanobactin.
Ethan B RobertsonJulia L E WillettPublished in: bioRxiv : the preprint server for biology (2023)
may overcome antagonism from mutanobactin through production of gelatinase, a secreted protease and prevalent virulence factor. Our results demonstrate the antibiotic and anti-biofilm potential of mutanobactin and highlight the role of bacterial proteases in resistance to bacteria- and host-derived antimicrobial compounds.