Glucose-dependent insulinotropic polypeptide monoclonal antibodies prevent and treat obesity in wild-type and hyperphagic mice.

M Michael Wolfe Caroline M ApovianMichael O Boylan

Published in: Obesity (Silver Spring, Md.) (2023)

These studies support the hypothesis that a reduction in GIP signaling appears to affect body weight without suppressing food intake and might provide a novel, useful method for the treatment and prevention of obesity.

Keyphrases

wild type
high fat diet induced
body weight
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
blood glucose
signaling pathway
adipose tissue
combination therapy
blood pressure
case control
replacement therapy