The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss.

Mila Fernandes Moreira MadeiraCelso M Queiroz-JuniorJôice D CorrêaSílvia M C WerneckFabiana S MachadoThiago M CunhaGustavo P GarletMauro M TeixeiraTarcília A SilvaDaniele G Souza

Published in: Journal of clinical periodontology (2017)

In conclusion, LTB4 but not CysLTs is important for Aa-induced alveolar bone loss. Overall, LTB4 affects osteoclast differentiation and activity and is a key intermediate of PAF-induced osteoclastogenesis.

Keyphrases

bone loss
high glucose
diabetic rats
drug induced
endothelial cells
inflammatory response