Histiocytic Sarcoma With CCND1 Gene Rearrangement Clonally Related and Transdifferentiated From Mantle Cell Lymphoma.

Jyoti KumarMustafa Al-KawaazBrock A MartinMohamed M HegaziBrent TanDita A Gratzinger

Published in: American journal of clinical pathology (2022)

To our knowledge, this is the first report to provide evidence for clonal evolution of histiocytic sarcoma from blastoid mantle cell lymphoma based on cytogenic and molecular findings. The patient's protracted therapeutic course may have acted as an evolutionary driver promoting this transdifferentiation process.

Keyphrases

genome wide
healthcare
case report
copy number
gene expression
genome wide identification
drug induced
genome wide analysis