Prognosis comparison between wait and watch and surgical strategy on rectal cancer patients after treatment with neoadjuvant chemoradiotherapy: a meta-analysis.
Kai PangQuan RaoShengqi QinLan JinHongwei YaoZhongtao ZhangPublished in: Therapeutic advances in gastroenterology (2019)
In contrast with patients undergoing surgical treatment, the W&W group has higher 3- and 5-year OS, and is not inferior on other major prognostic indicators, which, however, is based on the fact that the tumor stage in the W&W group is generally earlier. Versus surgically treated patients who acquired pCR, W&W group is inferior on all major prognostic indicators except 2-year DM/DM+LR and 3-year OS. Additionally, by comparison of cCR definitions across different studies, we conclude that implementation of the strictest cCR criteria is critical for W&W patients to acquire maximum prognostic benefit.
Keyphrases
- rectal cancer
- patients undergoing
- end stage renal disease
- locally advanced
- newly diagnosed
- ejection fraction
- chronic kidney disease
- healthcare
- primary care
- regulatory t cells
- magnetic resonance
- lymph node
- peritoneal dialysis
- magnetic resonance imaging
- prognostic factors
- quality improvement
- patient reported outcomes
- squamous cell carcinoma
- radiation therapy
- immune response
- glycemic control
- skeletal muscle
- clinical evaluation