Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling.

Ali QureishiGuillaume RieunierKetan A ShahTamara AleksicStuart C WinterHenrik MøllerValentine Moya Macaulay

Published in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2019)

Radiation upregulates IGF-1R and may enhance IGF/EGFR dependence, suggesting that IGF/EGFR blockade may have activity in LSCCs that recur post-radiotherapy.

Keyphrases

binding protein
pi k akt
growth hormone
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
early stage
radiation therapy
radiation induced
squamous cell carcinoma
cell proliferation
young adults
growth factor