Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats.

Priscila Vázquez-León Abraham Miranda-Páez Hugo Sánchez-Castillo Bruno A Marichal-Cancino

Published in: Pharmacological reports : PR (2023)

In general, stimulation/blockade of KOR in A-withdrawal animals exert higher responses compared to A-naïve ones. SAL-A produced anxiety-like behaviors and increased alcohol consumption/preference, especially/solely in the alcohol-withdrawal condition, while PF-04455242 augmented exploration with no effects on alcohol intake/preference. Our findings suggest a possible pharmacologic hyperreactivity of the KOR in PAG during alcohol withdrawal.

Keyphrases

alcohol consumption
chronic pain
nuclear factor
immune response
toll like receptor
sleep quality