The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana.

Heike WollmannHume StroudRamesh YelagandulaYoshiaki TarutaniDanhua JiangLi JingBhagyshree JamgeHidenori TakeuchiSarah HolecXin NieTetsuji KakutaniSteven E JacobsenFrederic Berger

Published in: Genome biology (2017)

We propose that H3.3 prevents recruitment of H1, inhibiting H1's promotion of chromatin folding that restricts access to DNA methyltransferases responsible for gene body methylation. Thus, gene body methylation is likely shaped by H3.3 dynamics in conjunction with transcriptional activity.

Keyphrases

genome wide
dna methylation
copy number
arabidopsis thaliana
gene expression
single molecule
transcription factor
genome wide identification
dna damage
signaling pathway
molecular dynamics simulations