Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability.

Xiaoyu LiuZhi LiZhongmin Wang Fei LiuLinling ZhangJingjing KeXu XuYuefang ZhangYiting YuanTao WeiQungang ShanYingjie ChenWei HuangJie GaoNan WuFuliang ChenLunquan SunZilong QiuYuezhen DengXiaojing Wang

Published in: Cancer research (2022)

This study links ARID1A loss with enhanced glycolysis in lung cancer and demonstrates the preclinical efficacy of BET inhibitor therapy as a strategy to combat tumor growth.

Keyphrases

gene expression
climate change
dna damage
transcription factor
genome wide
oxidative stress
dna methylation