Inhibition of γ-glutamyltransferase ameliorates ischaemia-reoxygenation tissue damage in rats with hepatic steatosis.

Ryuichi KubotaNobuhiko HayashiKaori KinoshitaTakashi SaitoKazuaki OzakiYoshimichi UedaMutsumi TsuchishimaMikihiro TsutsumiJoseph George

Published in: British journal of pharmacology (2020)

Treatment with GGsTop significantly increased hepatic glutathione content, reduced hepatic MDA, 4-HNE and HMGB1 levels and, remarkably, ameliorated hepatic necrosis after ischaemia-reoxygenation. The results indicated that GGsTop could be an appropriate therapeutic agent to reduce IR-induced liver injury in obesity and steatosis.

Keyphrases

insulin resistance
metabolic syndrome
induced apoptosis
high fat diet induced
type diabetes
oxidative stress
weight loss
breast cancer cells
mouse model
body mass index
cell proliferation
weight gain