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Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.

Hetal S ShahMario Luca MorieriSantica M MarcovinaRonald J SigalHertzel C GersteinMichael J WagnerAlison A Motsinger-ReifJohn B BusePeter KraftJosyf C MychaleckyjAlessandro Doria
Published in: Diabetes care (2017)
Differences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control. These findings highlight the importance of GLP-1 as a cardioprotective factor.
Keyphrases
  • glycemic control
  • type diabetes
  • blood glucose
  • weight loss
  • insulin resistance
  • genome wide
  • copy number
  • metabolic syndrome
  • adipose tissue