Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.
Hetal S ShahMario Luca MorieriSantica M MarcovinaRonald J SigalHertzel C GersteinMichael J WagnerAlison A Motsinger-ReifJohn B BusePeter KraftJosyf C MychaleckyjAlessandro DoriaPublished in: Diabetes care (2017)
Differences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control. These findings highlight the importance of GLP-1 as a cardioprotective factor.