Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.

Hetal S ShahMario Luca MorieriSantica M MarcovinaRonald J SigalHertzel C GersteinMichael J WagnerAlison A Motsinger-ReifJohn B BusePeter KraftJosyf C MychaleckyjAlessandro Doria

Published in: Diabetes care (2017)

Differences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control. These findings highlight the importance of GLP-1 as a cardioprotective factor.

Keyphrases

glycemic control
type diabetes
blood glucose
weight loss
insulin resistance
genome wide
copy number
metabolic syndrome
adipose tissue