The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma.

Zhang-Hua ChenShu-Mei YanXi-Xi ChenQi ZhangShang-Xin LiuYang LiuYi-Ling LuoChao ZhangMiao XuYi-Fan ZhaoLi-Yun HuangBin-Liu LiuTian-Liang XiaDa-Zhi XuYao LiangYong-Ming ChenWei WangShu-Qiang YuanHui-Zhong ZhangJing-Ping YunWei-Wei ZhaiMu-Sheng ZengFan BaiQian Zhong

Published in: Genome medicine (2021)

We portrayed the (epi) genomic evolution process of EBVaGCs, revealed the extensive genomic diversity of EBV between tumors and normal tissue sites, and demonstrated the synergistic activation of the PI3K and Wnt pathways in EBVaGCs, offering a new potential treatment strategy for this disease.

Keyphrases

epstein barr virus
copy number
diffuse large b cell lymphoma
stem cells
cell proliferation
single cell
dna methylation
combination therapy
genome wide
human health