Mechanically mixed γ-Al 2 O 3 and HZSM-5 (Si/Al = 50) with different mass ratio were utilized as support for Cu-Co higher alcohol synthesis catalysts prepared through incipient wetness impregnation. The textural and structural properties were studied using Ar low temperature adsorption and desorption, H 2 -temperature programmed reduction (H 2 -TPR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM) and catalytic performance measurements. The results indicated that the mechanically mixed HZSM-5 and γ-Al 2 O 3 supported copper-cobalt catalysts were superior to either γ-Al 2 O 3 or HZSM-5 supported ones with the same metal loading. The results revealed that using HZSM-5 and γ-Al 2 O 3 mechanically mixed benefited the dispersion of metallic phases and stronger synergetic functions between smaller nanoparticles containing copper and/or cobalt, which is essential for HAS from CO hydrogenation. Under working conditions of P = 5.0 MPa, T = 300 °C, V (H 2 ) : V (CO) : V (N 2 ) = 4 : 2 : 1 and GHSV = 7200 mL g -1 h -1 , mechanically mixed HZSM-5 and γ-Al 2 O 3 supported catalysts showed higher catalytic activity than those over single support. For CuCo catalysts upon support containing 50.0 wt% HZSM-5 and 50.0 wt% γ-Al 2 O 3 , the CO conversion was 21.3% and the C 2+ alcohol selectivity was 41.8%.