Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation.
Kobi WasnerSemra SmajićJenny GhelfiSylvie DelcambreCesar A Prada-MedinaEvelyn KnappeGiuseppe ArenaPatrycja MulicaGideon AgyeahAleksandar RakovicIbrahim BoussaadKatja BadanjakJochen OhnmachtJean-Jacques GérardyMasashi TakanashiJoanne TrinhMichel MittelbronnNobutaka HattoriChristine KleinPaul M A AntonyPhilip SeiblerMalte SpielmannSandro L PereiraAnne GrünewaldPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Our findings suggest that parkin coregulates mitophagy, mitochondrial biogenesis, and mtDNA maintenance pathways, thereby protecting midbrain neurons from neuroinflammation and degeneration. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.