Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.
Pius S FasinuN P Dhammika NanayakkaraYan-Hong WangNarayan D ChaurasiyaH M Bandara HerathJames D McChesneyBharathi AvulaIkhlas KhanBabu L TekwaniLarry A WalkerPublished in: Malaria journal (2019)
This study presents new evidence that primaquine-5,6-orthoquinone, the metabolite of primaquine reflecting the oxidative biotransformation pathway, is generated in erythrocytes, probably by non-enzymatic means, and may not require transport from the liver or other tissues.