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Sex similarities and divergences in systemic and muscle iron metabolism adaptations to extreme physical inactivity in rats.

Mathieu HoreauMelissa DelalandeMartine RopertPatricia LeroyerBrice MartinLuz OrfilaOlivier LoréalFrédéric Derbré
Published in: Journal of cachexia, sarcopenia and muscle (2024)
Taken together, these data support that, in rats (1) extreme physical inactivity differently impacts the distribution of iron in both sexes, (2) splenic erythrophagocytosis could play a role in this iron misdistribution. The higher iron concentrations in atrophied soleus from both sexes are associated with a decoupling between the increase in iron storage proteins (i.e., ferritin and myoglobin) and the decrease in levels of iron export proteins (i.e., FPN and FLVCR1), thus supporting an iron sequestration in skeletal muscle under extreme physical inactivity.
Keyphrases
  • iron deficiency
  • skeletal muscle
  • physical activity
  • mental health
  • insulin resistance
  • machine learning
  • type diabetes
  • metabolic syndrome
  • adipose tissue
  • electronic health record
  • drug induced