Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.

Anders Breinbjerg Cecilie Siggaard Jørgensen G Bragi Walters Jakob Grove Thomas Damm Als Konstantinos Kamperis Lilja Stéfansdóttir Janne P Thirstrup Britt Borg Clara Albiñana Bjarni Johann Vilhjalmsson Viðar Ö Eðvarðsson Hreinn Stefánsson Preben Bo Mortensen Esben Agerbo Thomas M Werge Anders Dupont Børglum Ditte Demontis Kári StefánssonSøren RittigJane Hvarregaard Christensen

Published in: The Journal of urology (2024)

Common genetic variants contribute to the risk of childhood DUI, and genes important in neuronal development and detrusor smooth muscle activity were implicated. These findings may help guide identification of new treatment targets.

Keyphrases

smooth muscle
urinary incontinence
genome wide association study
genome wide
bioinformatics analysis
early life
obstructive sleep apnea
sleep quality
dna methylation
gene expression
cerebral ischemia
depressive symptoms
botulinum toxin
blood brain barrier
replacement therapy
smoking cessation