Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice.

Victor Ifeanyi OkohHericles Mesquita CamposPâmela Yasmin de Oliveira FerreiraRobbert Mota PereiraYohanny Souza SilvaEvilanna Lima ArrudaBarbara PagliaraniGerlon de Almeida Ribeiro OliveiraLuciano Morais LiãoGabriel Franco Dos SantosBoniek Gontijo VazJosé Ricardo SabinoFernanda Cristina Alcantara Dos SantosElson Alves CostaAndrea TarozziRicardo MenegattiPaulo César Ghedini

Published in: The Journal of pharmacy and pharmacology (2024)

The glycosylation of CHR with β-d-glucose tetraacetate amplifies its neuroprotective effects, positioning LQFM280 as a promising lead compound for safeguarding against neurodegenerative processes involving oxidative stress.

Keyphrases

oxidative stress
blood glucose
high fat diet induced
ischemia reperfusion injury
induced apoptosis
type diabetes
diabetic rats
blood pressure
adipose tissue
metabolic syndrome
endoplasmic reticulum stress