Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture.

Alexander E Katz Min-Lee Yang Michael G Levin Catherine Tcheandjieu Michael R Mathis Kristina L HunkerSusan BlackburnJonathan L EliasonDawn M Coleman Natalia Fendrikova-Mahlay Heather L GornikMonita KarmakarHannah HillChang Xu Matthew ZawistowskiChad M BrummettSebastian Zöllner Xiang Zhou Christopher J O'DonnellJulie A DouglasThemistocles L AssimesPhillip S TsaoJun Z LiScott M Damrauer James C Stanley Santhi K Ganeshnull null

Published in: Circulation. Genomic and precision medicine (2022)

FMD and AAAs seem to be sex-dimorphic manifestations of a heritable arterial disease with a partially shared complex genetic architecture. Excess risk of having an AAA according to a family history of FMD may justify screening in family members of individuals having FMD.

Keyphrases

abdominal aortic
genome wide
copy number
gene expression
dna methylation