A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer's Disease.

Qiang ZengLongfei LiYu JinZongzheng ChenLihong DuanMeiqun Cao Min Ma Zhengzhi Wu

Published in: Evidence-based complementary and alternative medicine : eCAM (2019)

The ameliorative effects of PLP on AD were predicted to be associated with regulating neural cell apoptosis, inflammatory response, and neurotrophy via various pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, and neurotrophin signaling pathway.

Keyphrases

pi k akt
signaling pathway
cell proliferation
inflammatory response
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
genome wide
dna methylation
lipopolysaccharide induced
gene expression
lps induced
toll like receptor