Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder.

Ida Behrendt-Møller Trine MadsenHolger Jelling SørensenLouisa SylviaEdward S FriedmanRichard C SheltonCharles L BowdenJoseph R CalabreseSusan L McElroyTerence A KetterNoreen A Reilly-HarringtonKeming GaoMichael ThaseWilliam V Bobo Mauricio TohenMelvin McInnisMasoud KamaliJames H KocsisThilo DeckersbachAndrew A Nierenberg

Published in: Bipolar disorders (2018)

Approximately 30% experienced a partial or fluctuating course, and almost 10% had a chronic course with moderate-severe depression during 6 months. Patients diagnosed with bipolar type 1 had higher risk of being categorized into a class with a worse outcome. While no differences in average overall outcomes occurred between the lithium and quetiapine groups, trajectory analysis revealed that the lithium group had more variable courses.

Keyphrases

bipolar disorder
depressive symptoms
end stage renal disease
major depressive disorder
newly diagnosed
ejection fraction
type diabetes
peritoneal dialysis
single cell
high intensity
drug induced