IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice.

Xiaohai ZhouBowen TanWeiwei GuiCaiping ZhouHanxin ZhaoXihua LinHong Li

Published in: Molecular medicine (Cambridge, Mass.) (2023)

In summary, our findings strongly suggest that IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling. These results provide compelling evidence for considering IGF2 as a potential target for interventions aimed at slowing down the process of liver aging.

Keyphrases

pi k akt
binding protein
growth hormone
replacement therapy
high glucose
oxidative stress
risk assessment
metabolic syndrome
endothelial cells