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[Postmortem assessment of cerebral edema].

Aleksandr I ShchegolevU N TumanovaO V Savva
Published in: Arkhiv patologii (2022)
An analysis of literature data on the methods of post-mortem assessment of cerebral edema is presented. Based on the mechanisms of development, two main types of cerebral edema are distinguished: cytotoxic (intracellular) and vasogenic (extracellular). To determine cerebral edema, a number of methods are used, both direct and indirect, invasive and non-invasive assessment. Direct methods for assessing cerebral edema are based on determining the amount of water in its tissue. Indirect methods include morphological and radiation studies. Traditionally, the most evidence-based criteria for the diagnosis of cerebral edema are macroscopic and microscopic changes determined at autopsy. Methods are also indicated for determining the content of water in brain tissue by comparing the mass of wet and dry brain, as well as estimating the specific density of brain tissue.
Keyphrases
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  • cerebral ischemia
  • white matter
  • systematic review
  • brain injury
  • cerebral blood flow
  • multiple sclerosis
  • machine learning
  • electronic health record
  • reactive oxygen species