Effects of the Beijing genotype on latent tuberculosis infection, TB disease risk, and clustering of TB cases.

Michael Asare-BaahMarie Nancy SéraphinLaTweika A T Salmon-TrejoLori JohnstonLina DominiqueDavid AshkinKrishna VaddipartiAwewura KwaraAnthony T MaurelliMichael Lauzardo

Published in: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2024)

While the Beijing genotype did not increase the risk of LTBI or active TB among contacts, it showed a higher tendency for case clustering. Hence, interventions should prioritize populations where this genotype is prevalent.

Keyphrases

mycobacterium tuberculosis
air pollution
single cell
particulate matter
rna seq
pulmonary tuberculosis
physical activity
hepatitis c virus
hiv infected
genetic diversity