Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

Chittappen K PrajeethJulius KronischReza KhorooshiBenjamin KnierHenrik Toft-HansenViktoria GudiStefan FloessJochen HuehnTrevor OwensThomas KornMartin Stangel

Published in: Journal of neuroinflammation (2017)

Our results demonstrate the delicate interaction between T cell subsets and glial cells and how they communicate to mediate their effects. Effectors of Th1 act on both microglia and astrocytes whereas Th17 effectors preferentially target astrocytes to promote neuroinflammation.

Keyphrases

induced apoptosis
cell cycle arrest
type iii
inflammatory response
endoplasmic reticulum stress
oxidative stress
signaling pathway
lipopolysaccharide induced
spinal cord injury
brain injury
cognitive impairment