Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
Elizabeth TheuschFlora Y TingYuanyuan QinKristen StevensDevesh NaidooSarah M KingNeil Victor YangJoseph OrrBrenda Yuyuan HanJason G CysterYii-Der I ChenJerome I RotterRonald M KraussMarisa W MedinaPublished in: bioRxiv : the preprint server for biology (2023)
as a novel modulator of plasma cholesterol levels and statin response, suggesting that variation in ZNF335 activity could contribute to inter-individual differences in statin clinical efficacy.