Cell-Free DNA Detection of Tumor Mutations in Heterogeneous, Localized Prostate Cancer Via Targeted, Multiregion Sequencing.
Emmalyn ChenClinton L CarioLancelote LeongKaren LopezCésar P MárquezPatricia S LiErica OropezaImelda TenggaraJanet E CowanJeffry P SimkoRobin KageyamaDaniel K WellsJune M ChanTerence W FriedlanderRahul AggarwalPamela L ParisFelix FengPeter R CarrollJohn S WittePublished in: JCO precision oncology (2021)
Our findings demonstrate the potential of targeted cfDNA sequencing to detect somatic tissue alterations in heterogeneous, localized prostate cancer, especially in a setting where matched tumor tissue may be unavailable (ie, active surveillance or treatment monitoring).