CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis-Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation.

Tin-Lok WongKai-Yu NgKel Vin TanLok-Hei ChanLei ZhouNoélia CheRuby L C HooTerence Kin-Wah LeeStéphane RichardChung-Mau LoKwan ManPek-Lan KhongStephianie Ma

Published in: Hepatology (Baltimore, Md.) (2020)

Our findings indicate that the PRMT6-ERK-PKM2 regulatory axis is an important determinant of the Warburg effect in tumor cells, and provide a mechanistic link among tumorigenicity, sorafenib resistance, and glucose metabolism.

Keyphrases

signaling pathway
pi k akt
cell proliferation
transcription factor