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Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms.

Shiva KeshavaUsha R PendurthiCharles T EsmonL Vijaya Mohan Rao
Published in: Journal of thrombosis and haemostasis : JTH (2020)
Our data suggest that pharmacological concentrations of rFVIIa generate thrombin in hemophilia in both platelet-dependent and platelet-independent mechanisms.
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