Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms.
Shiva KeshavaUsha R PendurthiCharles T EsmonL Vijaya Mohan RaoPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Our data suggest that pharmacological concentrations of rFVIIa generate thrombin in hemophilia in both platelet-dependent and platelet-independent mechanisms.