Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model.

Aurigena Antunes de AraújoLorena de Souza AraújoCaroline Addison Carvalho Xavier de MedeirosRenata Ferreira de Carvalho LeitãoGerly Anne de Castro BritoDeiziane Viana da Silva CostaGerlane Coelho Bernardo GuerraVinicius Barreto GarciaMaria Laura de Souza LimaRaimundo Fernandes de Araújo Junior

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

Olmesartan at a dose of 10 mg/kg prevented the mucosal damage and inflammation associated with 5-FU-induced OM, increasing granulation and tissue repair.

Keyphrases

oxidative stress
angiotensin ii
diabetic rats
angiotensin converting enzyme
vascular smooth muscle cells
dna damage
induced apoptosis
ischemia reperfusion injury
radiation induced
heat shock
radiation therapy
binding protein
signaling pathway
endothelial cells
endoplasmic reticulum stress