Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD.

Nisha KurianTaylor S CohenLisa ÖbergErica De ZanGabriel SkogbergStefan VollmerEngin BaturcamPetter SvanbergBritta BonnPaul D SmithOuti VaaralaDanen M Cunoosamy

Published in: International journal of chronic obstructive pulmonary disease (2019)

Our data demonstrate the activation of MEK1/2 pathway in COPD and highlight a dual function of MEK1/2 inhibition in improving host defense responses whilst also controlling inflammation.

Keyphrases

chronic obstructive pulmonary disease
oxidative stress
pi k akt
lung function
electronic health record
innate immune
big data
cell proliferation
air pollution
cystic fibrosis