A naphthalimide-based fluorescent platform for endoplasmic reticulum targeted imaging.
Yiwei LiNan ZhangYan WangShanshan LuJing ShengXiangjun LiuYongbiao WeiDihua ShangguanPublished in: Chemical communications (Cambridge, England) (2024)
A series of naphthalimide dyes (TRNATR, MOTNAMOT, MPNAMP, TYNATY, PNAP and IZNAIZ) were designed and synthesized by altering the side chains of the naphthalimide. Without the need for ER-targeting groups, the first five dyes were found to specifically target the ER, likely due to their well-suited lipophilic properties. Furthermore, TRNATR and TYNATY were proven effective for studying ER stress, showing promise in tracking ER autophagy in living cells triggered by tunicamycin and nutritional starvation.
Keyphrases
- endoplasmic reticulum
- fluorescent probe
- living cells
- cancer therapy
- high resolution
- cell death
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- estrogen receptor
- aqueous solution
- single molecule
- drug delivery
- breast cancer cells
- mass spectrometry
- deep learning
- quantum dots
- single cell
- artificial intelligence