Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats.
Vinícius Rodrigues Taranto NunesPaula Vieira Teixeira VidigalMárcio Tadeu PereiraLuís Carlos Duarte LadeiraMarcelo Vidigal CaliariFabrício Marcus Silva OliveiraAina Liz Alves CesarAndré Augusto Gomes FaracoRafael Calvão BarbutoIvana Duval de AraújoPublished in: Acta cirurgica brasileira (2021)
Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.