Cerebral collaterals are associated with pre-treatment brain-blood barrier permeability in acute ischemic stroke patients.
Alexandre Bani SadrLaura MechtouffMarc HermierOmer F EkerLucie RascleCharles de BourguignonTimothe BoutelierAnna MartinEmanuele TommasinoElodie OngJulia FontaineTae-Hee ChoLaurent DerexNorbert NighoghossianYves BerthezenePublished in: European radiology (2024)
In AIS, collaterals and BBB disruption have been both linked to hemorrhagic transformation. Poor collaterals were associated with larger ischemic cores and increased BBB permeability on pre-treatment MRI. These findings could contribute to hemorrhagic transformation risk stratification, thereby refining clinical decision-making for reperfusion therapies.
Keyphrases
- cerebral ischemia
- blood brain barrier
- decision making
- endothelial cells
- subarachnoid hemorrhage
- liver failure
- acute myocardial infarction
- magnetic resonance imaging
- ischemia reperfusion injury
- computed tomography
- intensive care unit
- combination therapy
- oxidative stress
- acute coronary syndrome
- white matter
- resting state
- hepatitis b virus
- functional connectivity
- acute ischemic stroke
- atrial fibrillation
- mechanical ventilation
- aortic dissection
- cerebral blood flow