Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions.

Philippe CodronJulien CassereauPatrick Vourc'hCharlotte Veyrat-DurebexHélène BlascoSelma KaneVincent ProcaccioFranck LetournelChristophe VernyGuy LenearsPascal ReynierArnaud Chevrollier

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2018)

ALS cytological lesions are absent in patient-derived fibroblasts and thus cannot contribute as diagnostic nor prognostic markers of the disease.

Keyphrases

amyotrophic lateral sclerosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
extracellular matrix
peritoneal dialysis
patient reported outcomes
late onset