Recellularization of xenograft heart valves reduces the xenoreactive immune response in an in vivo rat model.
Sabin J BozsoJimmy J H KangRyaan El-AndariNicholas FialkaLin Fu ZhuSteven R MeyerDarren H FreedJeevan NagendranJeevan NagendranPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021)
Autologous mesenchymal stem cell recellularization of xenogenic valves reduces the xenoreactive immune response in an in vivo rat model and may be an effective approach to decrease the progression of xenograft valve dysfunction.
Keyphrases
- immune response
- aortic valve
- mesenchymal stem cells
- aortic valve replacement
- bone marrow
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic stenosis
- cell therapy
- toll like receptor
- mitral valve
- oxidative stress
- umbilical cord
- atrial fibrillation
- stem cells
- left ventricular
- inflammatory response