A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion.

Alexis VielJérôme HenriSalim BouchèneJulian LarocheJean-Guy RollandJacqueline ManceauMichel LaurentieWilliam CouetNicolas Grégoire

Published in: Pharmaceutical research (2018)

The WB-PBPK model gives an insight into the renal distribution and elimination of CMS and colistin in pigs; it may be further developed to explore the colistin induced-nephrotoxicity in humans.

Keyphrases

escherichia coli
acinetobacter baumannii
pseudomonas aeruginosa
klebsiella pneumoniae
gram negative
multidrug resistant
drug resistant
drug induced
high glucose
diabetic rats
cancer therapy
oxidative stress
endothelial cells
drug release
stress induced