Hyperacute immune responses associate with immediate neuropathology and motor dysfunction in large vessel occlusions.
Mudassir FarooquiSantiago Ortega-GutierrezKatherine HernandezVanessa O TorresAndres DajlesCynthia B ZevallosDarko Quispe-OrozcoAlan Mendez-RuizKenneth ManzelPatrick Ten EyckDaniel TranelNitin J KarandikarSterling B OrtegaPublished in: Annals of clinical and translational neurology (2022)
We provide evidence of the activation of the inflammatory adaptive immune response during the hyperacute phase and the association of pro-inflammatory cytokines with greater ischemic tissue and worsening recovery after successful reperfusion. Further characterization of these immune pathways is warranted to test selective immunomodulators during the early stages of stroke rehabilitation.
Keyphrases
- immune response
- cerebral ischemia
- oxidative stress
- subarachnoid hemorrhage
- blood brain barrier
- atrial fibrillation
- dendritic cells
- toll like receptor
- brain injury
- acute myocardial infarction
- ischemia reperfusion injury
- anti inflammatory
- acute ischemic stroke
- heart failure
- left ventricular
- inflammatory response
- coronary artery disease
- percutaneous coronary intervention