Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent.
Wenshu LinBing NiuJialin YiZhirui DengJiang SongQin ChenPublished in: BioMed research international (2018)
The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD's bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK+/- cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use.
Keyphrases
- oxidative stress
- high efficiency
- escherichia coli
- pet ct
- induced apoptosis
- liver failure
- oxide nanoparticles
- type diabetes
- gene expression
- cell cycle arrest
- respiratory failure
- adipose tissue
- genome wide
- dna methylation
- cell proliferation
- cystic fibrosis
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- wild type
- mechanical ventilation