Can we improve the outcome of pregnancies with low serum PAPP-A in the first trimester?

Valentina I TsibizovaBaydaa Al-SannanAnna FedorovaIgor GovorovArun MeyyazhaganGian Carlo Di Renzo

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2024)

The conclusion suggests that 200 mg per day of VMP4 up to 36 weeks of supplementation led to fewer placental-related complications in women with very low PAPP-A at first-trimester screening (0.399 MoM). By reporting lower rates of miscarriages, PBs, and fetal developmental abnormalities in the micronized progesterone-treated groups, the study suggests a potential reduction in complications.

Keyphrases

risk factors
gestational age
preterm birth
estrogen receptor
emergency department
pregnant women
risk assessment