DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
Pamela R Matias-GarciaCavin K Ward-CavinessLaura M RaffieldXu GaoYan ZhangRory WilsonXīn GàoJana NanoAndrew BostomElena ColicinoAdolfo CorreaBrent CoullCharles EatonLifang HouAllan C JustSonja KunzeLeslie LangeEthan LangeXihong LinSimin LiuJamaji C Nwanaji-EnweremAlex ReinerJincheng ShenBen SchöttkerPantel VokonasYinan ZhengBessie YoungJoel SchwartzSteve HorvathAke LuEric A WhitselWolfgang KoenigJerzy AdamskiJuliane WinkelmannHermann BrennerAndrea A BaccarelliChristian GiegerAnnette PetersNora FranceschiniMelanie WaldenbergerPublished in: Clinical epigenetics (2021)
DNAmAge acceleration and DNAm mortality predictors estimated in whole blood were associated with multiple kidney traits, including eGFR and CKD, in this multi-ethnic study. Epigenetic biomarkers which reflect the systemic effects of age-related mechanisms such as immunosenescence, inflammaging and oxidative stress may have important mechanistic or prognostic roles in kidney disease. Our study highlights new findings linking kidney disease to biological aging, and opportunities warranting future investigation into DNA methylation biomarkers for prognostic or risk stratification in kidney disease.