Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples.
Sharon BerendsenElselien FrijlinkJèrôme KroonenWim G M SplietWim van HeckeTatjana SeuteTom J SnijdersPierre A RobePublished in: Neuro-oncology advances (2019)
The in vitro effects of VPA on histone acetylation status in glioblastoma cells could not be confirmed in clinical tumor samples of glioblastoma patients using antiepileptic doses of VPA, which reflects the lack of effect of VPA on the clinical outcome of glioblastoma patients.