Impact of disease progression on individual IPSS trajectories and consequences of immediate versus delayed start of treatment in patients with moderate or severe LUTS associated with BPH.

Salvatore D'AgateTimothy WilsonBurkay AdaligMichael ManyakJuan Manuel Palacios-MorenoChandrashekhar ChavanMatthias OelkeClaus RoehrbornOscar Della Pasqua

Published in: World journal of urology (2019)

CTS allows systematic evaluation of immediate versus delayed combination therapy. Immediate response to α-blockers is not predictive of long-term symptom improvement. Observed IPSS differences between immediate and delayed combination therapy (6-24 months) are statistically significant.

Keyphrases

combination therapy
lower urinary tract symptoms
benign prostatic hyperplasia
depressive symptoms
early onset