Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.
Silvia Anahi Valdés-RivesDiana Casique-AguirreLiliana Germán-CastelánMarco Antonio Velasco VelazquezAliesha González-ArenasPublished in: BioMed research international (2017)
Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.
Keyphrases
- stem cells
- cell death
- signaling pathway
- cell cycle arrest
- oxidative stress
- endoplasmic reticulum stress
- papillary thyroid
- pi k akt
- endothelial cells
- transcription factor
- cell migration
- epithelial mesenchymal transition
- vascular endothelial growth factor
- squamous cell carcinoma
- resting state
- multiple sclerosis
- cell proliferation
- brain injury
- bone marrow
- young adults
- wound healing
- risk assessment
- subarachnoid hemorrhage