Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents.
Lucas MorenoSteven G DuBoisJulia L Glade BenderAudrey MauguenNicholas BirdVickie BuengerMichela CasanovaFrançois DozElizabeth FoxLia GoreDouglas S HawkinsShai IzraeliDavid T W JonesPamela R KearnsJan J MolenaarKarsten NysomStefan PfisterGregory H ReamanMalcolm A SmithBrenda J WeigelGilles VassalChristian Michel ZwaanXavier PaolettiAlexia IasonosAndrew D J PearsonPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
An optimized, agreed approach to the design and evaluation of early-phase pediatric combination trials will accelerate drug development and benefit all stakeholders, most importantly children and adolescents with cancer.